Recent research from Australia and New Zealand found kidney transplant recipients are 11 times more likely to die from skin cancer than the general population. This reinforces the need for ongoing regular skin surveillance and timely access to treatment for transplant recipients.
Skin cancer mortality in Australian and New Zealand kidney transplant recipients: A population-based cohort study using linked health data, 1990-2019
Abstract
Background: Transplant recipients have an increased risk of skin cancer and related death compared to the general population. How demographics or geography impact mortality is unclear. Understanding these will help identify groups at highest risk of skin cancer death.
Objectives: To estimate skin cancer mortality rates among kidney transplant recipients in Australia and New Zealand and describe excess mortality by demographics and geography, relative to the general population, and change over time.
Methods: We linked kidney transplant recipients from the Australia and New Zealand Dialysis and Transplant Registry with National Death Registers in Australia and New Zealand from 1990 to 2019. We identified deaths from melanoma (ICD-10 code C43), keratinocyte cancer (KC) (C44) and carcinoma in situ (D04) and estimated absolute mortality per 100,000 person-years (py) of follow-up. We used indirect standardisation to estimate standardised mortality ratios (SMR) with 95% confidence intervals (CI) for kidney transplant recipients compared to the general population by sex, age at death, decade of death, and New Zealand or Australian state.
Results: We included 21,503 individuals who received their first kidney transplant between 1990-2019. There were 251 deaths from skin cancer, 82 from melanoma and 169 from KC, in 212,317 person-years of follow-up (py). Absolute skin cancer mortality rate was 118.2 per 100,000py (95% CI 104.1-134.2); 38.6 per 100,000py for melanoma (95% CI 31.1-48.0), and 79.6 per 100,000py for KC (95% CI 68.5-92.6). Skin cancer mortality was 11.1-times higher in kidney transplant recipients compared to the general population (SMR) overall, 4.5-times higher for melanoma and 34.5-times higher for KC. Excess skin cancer mortality relative to the general population was observed in both sexes, across all age groups, residential areas and decades of follow-up. Excess mortality was highest in regions with high ultraviolet radiation (UV) indices – Australian states of Queensland (SMR 14.8; 95% CI 11.7-18.8), Western Australia (SMR 13.1; 95% CI 8.7-19.7) and in New Zealand (SMR 11.0; 95% CI 8.3-14.6)
Conclusions: Kidney transplant recipients are at increased risk of skin cancer death, especially from KC, in all demographics and regions, especially those with high UV indices. Enhanced surveillance and rapid treatment entry are warranted.
Reference:
Dana S Forcey, Brenda Maria Rosales, Melanie L Wyld, Nicole De La Mata, Kiarash Khosrotehrani, Angela C Webster, Skin cancer mortality in Australian and New Zealand kidney transplant recipients: A population-based cohort study using linked health data, 1990-2019, British Journal of Dermatology, 2026;, ljag232, https://doi.org/10.1093/bjd/ljag232